- Title
- Indexing cerebrovascular health using near-infrared spectroscopy
- Creator
- Afkhami, Rashid; Walker, Frederick R.; Ramadan, Saadallah; Wong, Rachel; Johnson, Sarah J.
- Relation
- Scientific Reports Vol. 11, no. 14812
- Publisher Link
- http://dx.doi.org/10.1038/s41598-021-94348-5
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2021
- Description
- Near-infrared spectroscopy (NiRS) is a relatively new technology of brain imaging with its potential in the assessment of cerebrovascular health only recently discovered. Encouraging early results suggest that NiRS can be used as an inexpensive and portable cerebrovascular health tracking device using a recently proposed pulse relaxation function (PReFx). In this paper, we propose a new NiRS timing index, TI NiRS, of cerebrovascular health. TI NiRS is a novel use of the NiRS technology. TI NiRS is motivated by the previously proved relationship of the timing of the reflected wave with vascular resistance and compliance in the context of pressure waveforms. We correlated both TI NiRS and PReFx against age, a non-exercise cardiorespiratory fitness (CRF) index, and two existing indices of cerebrovascular health, namely transcranial Doppler (TCD) augmentation index, AI TCD, and magnetic resonance imaging (MRI) blood flow pulsatility index, PI MRI. The TI NiRS correlations with Age, CRF, PI MRI and AI TCD all are significant, i.e., r= 0.53 (p= 0.002), r= - 0.44 (p= 0.011), r= 0.45 (p= 0.012) and r= 0.46 (p= 0.010), respectively. PReFx, however, did not have significant correlations with any of the vascular health factors. The proposed timing index is a reliable indicator of cerebrovascular aging factors in the NiRS waveform.
- Subject
- near-infrared spectroscopy (NiRS); cerebrovascular health; vascular stiffening; brain imaging
- Identifier
- http://hdl.handle.net/1959.13/1460760
- Identifier
- uon:46046
- Identifier
- ISSN:2045-2322
- Rights
- © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- Language
- eng
- Full Text
- Reviewed
- Hits: 2265
- Visitors: 2411
- Downloads: 151
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 1 MB | Adobe Acrobat PDF | View Details Download |